Getting to Alaska meant a stop in Seattle then a stop in Vancouver. When we hit Vancouver we stayed for a few days before boarding the boat. One regret about leaving the West Coast was that we never went back to Vancouver - I really liked it there. Not that it's inaccessible from Boston, it's just a whole lot closer to San Francisco.
The hotel we stayed in had a nice view of some new glass-encases highrise towers going up. The skyline was pretty enough.